This essay explores the relationship between the subject, nature, and the universe within the context of modern philosophy. The author critiques scientific objectivism and the notion of nature as an absolute, independent totality, as seen in Marxist philosophy of the time (e.g., Kosík). Drawing on Whitehead, Leibniz, and Teilhard de Chardin, the text proposes a new ontological model where the "subject" is not merely an observer but the fundamental building block of reality, defined as a temporal event or process. This subjectivity extends across all levels of existence, from subatomic particles to human beings. Central to the argument is the concept of reactivity, through which subjects integrate external influences into a coherent whole. The author concludes that the universe is not a static collection of objects but a pluralistic creation of high-level subjects who interlink their worlds. Ultimately, the philosophy of man must lead to a re-conceptualization of the universe where nature is integrated into the human world and progressively humanized, rather than viewed as a separate, indifferent realm.