This text examines the relationship between the concepts of entropy and negentropy, providing a critical reflection on the traditional scientific discussions held within theoretical biology after World War II. The prevailing consensus at the time suggested that negentropic processes were secondary and dependent on entropic ones, leading to further investigation into the distinctions between open and closed systems. However, the author challenges this established assumption by presenting a logical counterargument that reverses the hierarchy of these concepts. He argues that negentropy cannot be a mere derivative of entropy, as entropy, understood as a process of degradation and the decay of order, fundamentally requires the existence of an initial ordered state to act upon. Without primary negentropy, the entropic process would lack both its object and its direction. The reflection concludes that negentropy is a necessary ontological prerequisite for the existence of entropy, thereby opening space for a new interpretation of thermodynamic laws within biological and physical systems.