The text examines the ontological distinction between external and internal relationships within the context of the integration of entities and organisms. The author emphasizes the necessity of differentiating genuine relationships between subjects from formal ones and from internal ties that establish the unity of a whole. Using Whitehead's theory of organism as an illustration, the text describes how a living whole integrates common physical elements, such as atoms and electrons, into specific structures modified in the spirit of the entity's overall integrity. The work challenges the reductionist notion that life can be mechanically or chemically synthesized from the outside through a mere selection of atoms and molecules. It argues that while chemistry can identify the material components necessary for life, it remains unable to grasp the internal activities rooted in future possibilities that are essential for the emergence and sustenance of a living body. The core of the argument lies in the irreducibility of internal integrity and dynamics, which fundamentally transcend the mere external interaction of material components.