This text addresses the profound philosophical problem of the beginning, encapsulated by the ancient Greek term arché, within the context of the contemporary dissolution of substantialist thought. The author posits that since nothing remains static, understanding reality requires moving beyond the comparison of fixed states to grasp the continuity of change, characterized as an event with a distinct beginning, progression, and end. A central challenge is explaining how such an event originates. A genuine beginning cannot be fully determined by prior conditions; instead, it requires an active performance by the event itself to integrate external elements into its own emerging integrity. This necessitates the event establishing itself as a subject and a source of activity. The author argues that this problem of initiation—how a whole begins to act as a unified entity—is a fundamental issue not only for philosophy but also for modern theoretical physics and biology. Thus, the ancient concept of arché is re-evaluated and reformulated to address the origins of both individual organisms and the universe as a whole.